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Imaging CFTR: A tail to tail dimer with a central pore

462 Addictive disorders Glutamatergic transmission regulates reward circuitry and dopaminergic connectivity

PMID: 26817506

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(2019) reveals that TDP-43 phase separation is not just a biophysical occurrence, but a central pathological mechanism in ALS and FTD, addressing the view of aggregation as a passive consequence to a dynamic and stress-induced process with functional consequences on nuclear transport and cellular survival

One potential mechanism could be increased prevalence of NAION risk factors in patients starting GLP-1RA or that sudden and rapid decline in blood glucose could increase the risk of diabetic papillopathy or worsened DR