A single trial evaluated tirzepatide for HFpEF, which included patients with and without T2DM, and showed improvement in a composite outcome of death from CV causes or worsening HF symptoms of HFpEF when compared to placebo
Approach: 1.2-1.4g protein per kg body weight daily (track with an app) Iron supplementation to maintain ferritin above 50 ng/mL 30mg zinc daily with 1mg copper 5,000 IU vitamin D daily (adjust based on levels) 5,000mcg biotin daily B-complex supplement Collagen peptides 10-15g daily (provides glycine and proline for hair structure) Baseline labs before starting, repeat at months 3, 6, and 9 Consider starting 2% minoxidil preventively Monthly hair progress photos Minimum 1,400 calories daily even when appetite is low Expected outcome: Mild shedding possible around months 4-6, generally self-limiting with recovery beginning by month 8-9
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Different Pattern of Volume Loss GLP-1-induced changes may affect facial fat compartments differently than natural aging or traditional weight loss, requiring specifically targeted treatment approaches
(2.8 to 4.2 kg) of weight loss has been reported with GLP-1 agonist use
If semaglutide left out overnight remained within acceptable semaglutide room temperature limits, it may still be usable depending on product guidelines
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