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As a result of being peptides, GLP-1 RAs typically have to be given by subcutaneous (s.c.) administration as twice daily (BID) (exenatide) [15, 16], once daily (OD) (lixisenatide [17, 18] and liraglutide [19, 20]) or once weekly (OW) (dulaglutide [21, 22], prolonged-release exenatide [23, 24] and semaglutide [25, 26]) dosing regimens, based on their in vivo half-lives [6]

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metformin, which treats insulin resistance

Data are represented as mean standard error of the mean (SEM)

During fertility treatments, GHKCu could be used to stabilize local hormonal environments, for example, reducing inflammatory factors that blunt follicle response or protecting testicular cells during assisted procedures