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Bold biology with a distinct receptor focus

The arrival of highly effective weight-loss medications has changed whats possible, but it has also changed our expectations

Venkatesh, S., Deecaraman, M., Kumar, R., Shamsi, M

Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised

This commentary discusses in more detail some of the potential mechanisms by which UV radiation could generate BRAF V600E mutations

The AAFP advises that injectable therapy leads to more rapid improvement and should be considered in patients with severe deficiency or severe neurologic symptoms (Langan RC, Goodbred AJ, 2017)