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However, a study (Zhakeer et al., 2017) of bufalin effect on asthmatic response in a mouse model, has demonstrated that this CTS (in a dose 5 and 10 mg/kg) significantly attenuated hyperresponsiveness and strongly suppressed the ovalbumin (OVA)-induced increase of total amount of inflammatory cells including macrophages, eosinophils, lymphocytes, and neutrophils in bronchoalveolar lavage fluid (BALF)

Thus, a lot of onus is on refining animal models and improving patient stratification to consider individual genetic and phenotypic variations in neurological diseases for the success of NP-based systems in clinical practice

2019;28:17171728.e6

The evidence is relatively strong

Epidemiology and radiological geometric assessment of pituitary macroadenomas: population-based study

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells