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(2015) 54:R3153
It allows the body to adjust while progressively increasing the metabolic benefits
For accumulation of a drug it is useful to predict that 50% accumulation is reached after one half-life and 75% after 2 half-lives
Activation of hypothalamic GLP-1 receptors enhances satiety signaling by influencing neurons that express pro-opiomelanocortin (POMC) and neuropeptide Y (NPY), mechanisms that reduce excessive food intake and the metabolic load tied to obesity [17,24]
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