The hair shedding associated with GLP-1 class medications, including retatrutide, is primarily caused by the metabolic stress of rapid weight loss , not by direct drug toxicity to follicles
Further, they highlight cell wall homeostasis as an important target of zinc-limitation in these and likely other ways
Actinomyces (121, 122), Prevotella (123), Bacteroides (120, 124), EscherichiaShigella (125) are the main species increased, whereas Mycobacterium , Lactobacillus , Enterobacter (123), Deltaproteobacteria , and Clostridiaceae decreased (126), including CB , FP , Clostridium leptum , Clostridium cluster XlVa , Clostridium cluster XlVb , Clostridium cluster XVIII (127)
Cell culture studies showed that GSH deficiency induced in vitro caused increased oxidative stress, downregulation of VDBP/VD-25-hydroxylase/VDR, upregulation of CYP24A1 in hepatocytes, and downregulation of PGC-1/VDR/GLUT-4 in myotubes [56]
This is to reduce the risk of any potential AAF arising after high doses are taken at once
Researchers note that the 12mg cohort had not reached a weight loss plateau at 48 weeks, suggesting efficacy may continue to increase with longer exposure
