The innovation underlying dual and even triple receptor agonists lies in their single-molecule architecture, which represents a significant advancement in peptide bioengineering
Additionally, the lncRNA H19 regulates chemotherapy resistance in breast cancer via the DNA damage response pathway [93]
Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival
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Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)