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GSR utilizes NADPH, derived from the PPP (of which G6PD catalyzes the first committed step), for recycling oxidized glutathione disulfide to reduced glutathione (Fig

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Any tissue that is damaged needs to be repaired by the immune system

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Natural antioxidants are likely to be less powerful and less reliable in terms of outcome but they are not as linked with side effects, increased price and potential to hamper basic cancer treatment [234, 235]