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In this state, the peptide is at its most stable because the absence of water slows hydrolytic degradation to near zero

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It is not necessary to withhold vitamin B12 therapy until the precise cause of B12 deficiency is established since absorption studies can be performed at any time

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Current FDA approved pharmaceutical treatment for acute ischemia is limited to thrombolytic intervention, which functions to restore blood flow, yet patients often still suffer long term motor, behavioral, and cognitive deficits due to a lack of interventions focused on promoting neuronal post-stroke recovery (Stubblefield and Lechleiter, 2019)

200 mg doses have been used and cumulative doses as high as 1000 mg have been given