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It comes from a structured clinical development program that tested exactly this question

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Mast cells are activated upon allergen-induced cross-linking of FcRI-bound IgE on their plasma membrane surface

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Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity of Cd.Cd induced oxidative stress by producing hydroxyl radicals, superox- ide anions, nitric oxide and hydrogen peroxide [25]