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a number of therapeutic approaches are under investigation, including targeting of Nrf2

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Because embryonic stem (ES) cells give rise to all the tissues in an organism, mechanisms are in place to avoid the accumulation of DNA to prevent mutations that would transmit to tissues and subsequent generations

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Individuals considering extended protocols should discuss this temporal limitation with healthcare providers and maintain appropriate monitoring throughout treatment

It seems that metabolic stress during obesity and metabolic syndrome induces a compensatory response, being characterized by increased Zn-mediated mechanisms of antioxidant protection