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La evidencia disponible es mayoritariamente preclnica (in vitro y en animales) y su traduccin a humanos permanece no establecida

Increasing evidence suggests that this axis exerts a profound influence on key neurobiological processes, including neuroinflammation, BBB permeability, neurotransmission, and synaptic plasticity, all of which are directly relevant to neurodegeneration and neuroprotection [615, 616]

Cell lysates were then collected, and bound L1 was detected by non-reducing SDS-PAGE and western blot

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Studies have investigated NNMT inhibition in the context of obesity, metabolic dysfunction, lipid accumulation, and energy-expenditure models, with research also exploring effects on adipocyte differentiation and methylation pathways