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Notably, bile acids form a dynamic regulatory network through enterohepatic circulation

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In HUVECs under hypoxic conditions, ROS production also increased and impaired microtubular structure via the PI3K/Stathmin 1 pathway [155]

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We used HepG2 cells treated with Oleic Acid (OA) as a model of hepatic steatosis in this study to see if direct activation of the GLP-1R with Ex-4 affects any of the four processes listed above and thus improves steatosis