Future developments affecting us may not be those that we have anticipated
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Effects of novel dual GIP and GLP-1 receptor agonist tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes
Thyroid, kidney, liver, lipid profile, HbA1c, and where relevant, hormonal panels
Initially developed for T2DM, these drugs have proven to be highly effective in reducing body weight and improving metabolic health in adolescents with obesity
For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]