It is interesting to note that the positive effect of tirzepatide on body weight is associated with a significant improvement in quality of life and physical performance [50] and is independent of sex [51], baseline body mass index (BMI) [52] and potential side effects, predominantly gastrointestinal [53]
Cartwright MJ, Tchkonia T, Kirkland JL
Mir Ali, MD, board certified general surgeon, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, not involved in this research, said that this study was helpful to show that some muscle can occur with significant weight loss. We see this in our surgical weight loss patients as well, and try to emphasize methods to minimize muscle loss, he told MNT
For example, comparing Mounjaro vs Wegovy shows both medications share similar side effect profiles, though individual responses can vary
Metabolic dysfunction-associated steatotic liver disease (formerly called NAFLD) affects roughly 30% of adults globally and has no approved pharmacotherapy
Coverage requirements typically include BMI over 30 (or over 27 with comorbidities), documented failed lifestyle interventions, physician letter of medical necessity, and ongoing monitoring
