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Carel le Roux, MD, PhD, can be reached at [email protected].

Most people adapt well to this change, though some experience altered fat digestion

In the primary Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023), retatrutide was studied across several dose levels, including: 1 mg (low dose) 4 mg (mid dose) 8 mg (higher dose) 12 mg (highest dose) These doses were administered as once-weekly subcutaneous injections

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This is also true for patients who rely on opioids (a type of strong painkiller) to manage chronic pain