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Consistent with these findings, an updated meta-analysis of thirteen phase 2 and phase 3 RCTs (n = 1,811 participants) showed that GLP-1RAs, especially semaglutide 2.4 mg weekly, significantly reduce hepatic fat content, promote MASH resolution, and improve liver fibrosis in patients with MASH, regardless of T2DM status (Mantovani et al., 2025[42])

Furthermore, GIPR antagonists increase metabolism in obese mice, and when combined with GLP1RAs, both GIPR agonists and antagonists have beneficial therapeutic effects

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