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Sergey Terushkin, MD, FACS, FASMBS leads Florida Surgery & Weight Loss, one of South Floridas top clinics for medical and surgical weight loss

Research in adipocyte cell models has demonstrated that the fragment activates beta-3 adrenergic receptor-related signalling in fat cells, increasing intracellular cAMP and activating hormone-sensitive lipase (HSL) the key enzyme in triglyceride hydrolysis resulting in increased free fatty acid release from adipose tissue

Zepbound contains tirzepatide, the same active ingredient as Mounjaro, and is FDA-approved for weight loss

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Ethics statement The study was performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments

ClinicalTrials.gov (ClinicalTrials.gov identifier NCT00044213)