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5a), approved for the treatment of amyotrophic lateral sclerosis, increases ROS levels by multiple mechanisms, including decreasing LDH-A and NAD + levels to increase oxidative stress, as well as interfering with the xCT antiporter to block the cystineglutamate pump

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This rapid absorption could be useful if a study requires quick results or precisely timed dosing

DSIP was dissolved in saline and injected intraperitoneally at a dose of 120 g/kg, 20 minutes prior to placing the animal into the hypoxic chamber