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Zhenqi Liu and former UVA graduate student Nathan Weeldreyer, found about 40% of the weight people lose using brand-name drugs like Wegovy or Zepbound comes from something called fat-free mass, which is everything in your body that is not fat

Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

Regardless of which site you prefer, rotation is essential

However, no GLP-1 patch has received FDA approval, and scientific evidence supporting their effectiveness remains absent

Ryan DH, Yockey SR

Studies show that patients typically regain 50-70% of lost weight within one year of stopping treatment