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10.3831/KPI.2020.23.008 263 ShiP.XieS.YangJ.ZhangY.HanS.SuS.et al (2022)

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Inhibitors of GH Secretion Several factors can suppress GH release: Somatostatin (also from the hypothalamus) directly inhibits GH secretion Hyperglycemia (high blood sugar) Elevated IGF-1 levels (negative feedback) Chronic stress or high cortisol levels Poor sleep and circadian disruption GHRH Analogues: Peptides That Mimic Natural Signals Several peptides have been developed to mimic the action of GHRH, improving GH release in a physiologically balanced way