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Challenges for Achieving and Maintaining Weight Loss, and Pharmacotherapeutic Options for Obesity Obesity is a chronic disease associated with high rates of relapse after achieving initial weight loss [10, 11]

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Differential diagnosis: Enlarged nucleolusone or more deeply basophilic structures in normal size nuclei

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Human leptin deficiency was associated with early-onset morbid obesity and metabolic syndrome without SNS activation or hypertension (Ozata et al., 1999)