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This allows the full dose to be absorbed and reduces the chance of medication leaking from the injection site

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50 A recent meta-analysis including thirteen RCTs has shown that semaglutide and tirzepatide treatment significantly increases GI side effects such as nausea, vomiting, diarrhea, and constipation in obese individuals without diabetes compared to control groups

In rodent models, activation of the GLP-1 neurons also results in activation of stress responses, including anxiety-like behavior (Maniscalco and Rinaman, 2018)