[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Hager K., Marahrens A., Kenklies M., Riederer P., Mnch G
Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in diet-induced obesity mouse model
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In this model, insulin signaling is much reduced in the brain by STZ, and tau phosphorylation is enhanced
Three distinct failure modes explain the historical record of oral peptide and protein failure: (1) Exposure infeasibility: A short elimination half-life prevents accumulation to a therapeutic body burden at low oral bioavailability, regardless of how sophisticated the formulation technology
Three physiological GPX4 isoforms, including cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), have been identified