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These alterations of renal energy and substrate metabolism may result from inherent abnormalities, including genetic defects, attempts of the kidneys to respond to environmental stressors, such as high-salt intake, or a combination of internal and external factors

Nature 415 , 9296 (2002)

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Cardioprotective effects and mechanism of action of polyphenols extracted from propolis against doxorubicin toxicity

For most healthy adults, yes

With a 10mg vial, you could reconstitute with a proportional amount of water to create a solution you will use entirely within the 28-day window