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Decreased leptin levels, a hormone produced by fat cells that signals energy availability to the brain, may affect the pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus

Insights from a metabolic surgery matched-cohort study

Most of the information we have comes from smaller studies or individual case reports

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He added that GLP-1s like tirzepatide (found in Mounjaro and Zepbound) offer slightly more weight loss with fewer side effects than semaglutide, likely because tirzepatide mimics both GLP-1 and GIP, gut hormones released after eating

No specific guidelines exist for microdosing