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Tirzepatide, a newer GLP-1/GIP receptor agonist, activates two separate appetite pathways rather than one, making it effective for patients who've stopped responding to single-agent GLP-1 therapy

Even so, in healthy adults, even with strict vegetarian patterns, a clinical deficiency is uncommon because endogenous synthesis usually meets needs, although context (age, nutritional status, illness) can modify this situation

Our results revealed that the consecutive application of semaglutide improved cardiac function

[PubMed: 31196815] 189

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