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Lipoic acid was found to effectively slow disease progression when administered either orally (87), intraperitoneally (88), or subcutaneously (89) to mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis

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Retrieved May 2, 2023

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So the first honest distinction is structural: tesamorelin is a modified full-length analog engineered for resistance to degradation, whereas sermorelin is an unmodified short fragment that reproduces GHRH activity but not GHRH stability