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Abstract Heart failure (HF) remains one of the cardiovascular diseases (CVDs) associated with a high unmet medical need due to high morbidity and mortality rates and lack of efficacious interventions

Herbal products have varying levels of evidence

The effects of tirzepatide on body weight control have also been confirmed in non-diabetic individuals in the SURMOUNT-1 study, where treatment with tirzepatide 1015 mg was associated with an average weight loss of approximately 20% at 72 weeks, exceeding 25% in one third of the patients

For weight management, NICE (TA664) recommends these medications within specialist weight management services for people with a BMI of at least 35 kg/m (or 32.5 kg/m in people from minority ethnic backgrounds) with non-diabetic hyperglycaemia and a high risk of cardiovascular disease, or a BMI of at least 30 kg/m with type 2 diabetes

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doi: 10.1042/bj3210583