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Many patients require dual or triple therapy when metformin alone proves insufficient, and the pairing of a GLP-1 receptor agonist with an SGLT2 inhibitor typically represents part of a stepwise treatment intensification approach to address multiple pathophysiological aspects of diabetes

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By inhibiting NNMT, 5-Amino-1MQ has been investigated for its potential to increase intracellular NAD+ levels and modulate lipid metabolism in preclinical settings

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Both groups experienced reductions in BW and body fat by weeks 4, 8, and 12 of the study

doi: 10.1111/imr.12285 142 ChoulakiCPapadakiGRepaAKampourakiEKambasKRitisKet al