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Together with its role in glutamate excitotoxity, NO could contribute to oxidative stress mechanisms in the pathogenesis of PD by interacting with ferritin to release iron, inducing mitochondrial complex I damage (Molina et al., 1998), and by inducing nitrosylation of proteins (Fernndez et al., 2013)
Clinical studies suggest that IGF-1 levels correlate with greater lean body mass and reduced fat percentage in trained individuals
Folic acid is best known for its role in megaloblastic anemias
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