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Moreover, it should be considered that the ability of GLP-1R agonists to pass the bloodbrain barrier varies, and their ability to activate different brain regions may vary (68, 69)

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These findings indicated that TGF-1 + IL-1 was sufficient to induce fibroblast activation by activating NLRP3 inflammasome, but insufficient to cause NLRP3/caspase-1/GSDMD-mediated fibroblast pyroptosis, while the underlying mechanism remains to be further explored

Here we investigate hepatic adaptation to acetaminophen toxicity from a whole proteome perspective, using quantitative mass spectrometry

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