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De novo design of peptides binders targeting the TMD of the insulin receptor Starting from the predicted homodimer structure of the TMD of the IR, we used Rosetta Design, which includes the Rosetta fast relax 53 and fixbb protocols 54 , to design potential peptide binders 55

Finkelstein, J

Ischemic stroke was obtained from MEGASTROKE consortium (34,217 cases and 406,111 controls) [25], the UK Biobank (7961 cases and 384,003 controls), and Finngen Biobank (10,551 cases and 208,241 controls) [26]

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FIGURE 2 3 Clinical applications of GLP-1RAs: comprehensive protection through multi-disease risk reduction 3.1 Cardiovascular protection GLP-1RAs confer substantial cardiovascular benefits that extend beyond glycemic control, primarily by reducing the incidence of major adverse cardiovascular events (MACE)