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It may modulate TCA cycle activity via secondary messengers like cAMP, though further validation is needed (263)

Although linear uptake of choline was observed for FLVCR1 and FLVCR2 (Fig S1C), saturation kinetics could not be obtained, despite adding up to 2 mM ethanolamine, which is 1,000-fold above the physiological concentration in blood of 2 M (Fig S1D) (14, 36)

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(More information) Thiamin deficiency can result from poor dietary intake, inadequate provision in parenteral nutrition, reduced gastrointestinal absorption, increased metabolic requirements, or excessive loss of thiamin

It is important to note that these medications should be used under the guidance of a healthcare provider and as part of a comprehensive weight management plan