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Their ability to selectively target senescent cells while sparing healthy tissues represents a paradigm shift in therapeutic intervention, offering new avenues for personalized oncology medicine

L-carnitine supports the transport of fatty acids into the mitochondria, where they are used as an energy source

As observed in other organ models, most reported kidney-on-chip studies still rely on immortalized cell lines (176180), although recent work has increasingly explored patient-derived primary cells, spheroids, and organoids to establish autologous renal chips (166, 181185)

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*Correspondence: Yongfu Fan, [email protected]