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Differences between species relate only to the rate of metabolism, but this is always rapid

Clinical evidence, as summarized in Table 1, includes studies showing that Empagliflozin improved oxidative stress markers and NYHA functional class in T2DM patients with HFrEF (Eshraghi et al., 2025), and Dapagliflozin reduced the number of AHREs and improved oxidative stress/mitochondrial function in the clinical AF subgroup of patients with CIEDs (Nantsupawat et al., 2024)

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