It has been reported that GSH is reduced by the following side reactions under neutral conditions (Methods in Enzymology, 1985, 113, 548)
The reaction rate was found to be in a linear correlation with the GSH concentration (Fig
The response to this release is bronchoconstriction and vasodilation which are the general symptoms associated with asthma and various allergic reactions
Oxidative and nitrosative stress in brain mitochondria of diabetic rats
Thus, although there is a low risk of cross-reactivity as exhibited by the urticarial reaction, there was no significant evidence to suggest that a self-reported sulfa allergy is likely to produce a life-threatening cross-reaction with either medication
Studies on GSTO1-1 also suggested a protective effect of this enzyme on PD, exerted through the inhibition of the active form of interleukin-1 (IL-1 ) which is a critical factor in inflammatory response 47,58