semaglutide cardiovascular outcomes news today 2025 SELECT Trial Recent study at UC Irvine

As briefly mentioned before, repeated injections in the same spot can lead to tissue damage, irritation, lipohypertrophy, a condition where fatty lumps form under the skin, or lipoatrophy, a condition that causes fat loss resulting in dents under the skin

For maximum weight-loss and hepatic-fat research endpoints, retatrutide leads with 24.2% mean body-weight loss (Phase 2), driven by its unique triple GLP-1/GIP/glucagon receptor agonism

Semaglutide also works on our stomach and causes the food to stay in the stomach for a longer period of time which causes delayed gastric emptying

The clearest sign that your semaglutide dose is effective is reduced appetite and consistent, measurable weight loss over several weeks

People who have a history or family history of a rare thyroid cancer (medullary thyroid carcinoma) should not use this medication, says Gudzune

"The next step is to investigate whether the medication reaches the joints in sufficient quantities and actually reduces inflammation in the joints." About the Study The research was a translational clinical biomarker study that examined paired blood and joint fluid samples from patients with inflammatory arthritis, including rheumatoid arthritis and spondyloarthritis