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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Raghu G., Noth I., Martinez F

They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

Storage and reconstitution timing also matter

Addressing these areas will not only deepen the understanding of ferroptosis in ADPKD but also accelerate the translation of targeted strategies into effective, safe therapies for this common hereditary kidney disease

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