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The reduction of GSSG to GSH is accompanied by the oxidation of NADPH to NADP+, leading to a decrease in absorbance at 340nm

The safety profiled show that 36 patients (43.9%, 36/82) had adverse effects

Published 1999

However, parasites quickly develop resistance against these antimalarials

Therefore, it is urgent to obtain potent ferroptosis inhibitors with good biocompatibility, strong stability and high safety by target-based or cell-based high-throughput screening, structural modification and other methods

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