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The reasoning is that your GLP-1 receptor tolerance from semaglutide means the GLP-1 component of tirzepatide will not overwhelm your system, and the GIP component alone is unlikely to cause severe side effects at this dose

Low titers of serum autoantibodies, such as antinuclear antibodies (ANA) and anti-smooth muscle antibodies (SMA), are commonly observed in MASLD (34 %) often as incidental findings without clinical significance [6]

My first thought was: no wonder people are having problems

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