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Furthermore, with average wait times for neurology specialists now exceeding a month, patients are often losing the critical window for immediate repair, allowing acute injuries to calcify into chronic Post-Concussion Syndrome (PCS)

Psychol Sci 2015;26:7508

Sigalos JT, Pastuszak AW

BBB disruption in age and neurodegenerative disorders Disruption of the BBB coincides with healthy aging, but the characteristics of breakdown can become further exacerbated in neurodegenerative disorders (Table 1)

Further, the miR-143 expression has also been reported to be increased in curcumin-treated DU145, LNCaP, and PC3 cells, leading to reduced migration and growth potential and increased sensitivity to radiation therapy [71, 72]

We conducted a wide range of additional control experiments to make sure we were looking at a true Orai1 deficiency phenotype. The investigators also created genetically modified mice that lacked Orai1 channels in excitatory neurons, but retained them elsewhere in the body and the brain