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Valsartan No clinically significant pharmacokinetic interactions were observed when valsartan was coadministered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin

The most common side effects are gastrointestinal nausea, constipation, or mild reflux and are usually manageable with gradual dose titration and dietary adjustments