In mice, the loss of JNK1 and JNK2 led to more severe age-related OA and ageing of cartilage and synovium (Loeser et al., 2020), an indication that JNK is a detrimental regulator of joint degeneration
Withdrawal requires downregulation of endogenous production or receptor adaptation that creates rebound symptoms when the substance is removed
Comput Intell Neurosci 2022:8066126 Kim DU et al (2021) Loganin attenuates the severity of acute kidney injury induced by cisplatin through the inhibition of ERK activation in mice
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung fibrotic disease that results in the thickening of alveolar walls and diminished lung function [103]
1 Introduction Neurodegenerative diseases (NDDs) comprise a heterogeneous group of disorders characterized by the progressive loss of neurons or myelin in the brain and spinal cord, including Alzheimers disease (AD), Parkinsons disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntingtons disease (HD) (Wilson et al., 2023)
Furthermore, after being sprayed on the upper leaves, MSNs-ss-SA was detected in the lower leaves, indicating its high penetration efficiency and rapid translocation capacity in rice plants
