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This contrasts with some single-pathway therapies that may show diminishing returns over time due to physiological adaptation or disease progression

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In a paradoxical fashion, postprandial hyperglucagonemia a common finding in T2DM contributes to glucose excursions in the fed state

High-Risk Contexts Although GLP-1RA therapy is generally safe and effective, the flux-constraint framework suggests that certain populations may be more sensitive to substrate imbalance during sustained hypophagia