doi:10.1016/S0196-0644(94)70071-0
Treating the off-period as a "half-dose" period (off means off, completely)
Both medications carry a similar risk of gastrointestinal side effects, including constipation
The IGF-1/IGF-1R axis can also induce phosphorylation of ER through ribosomal S6 kinase 1 (S6K1), downstream of the PI3K/AKT/mTOR pathway which results in the upregulation of IGF-1, IGF-1R and other ER target genes (Kim et al., 2007)
Long-Term Effectiveness The long-term effectiveness of sertraline is also noteworthy
Reframing newness to communicate the track record Patients sometimes equate new drug with unknown risk. For many individuals, hesitation toward GLP-1RA therapy stems from broader mistrust in the healthcare system, previous negative experiences with medications, or a preference for natural or holistic approaches