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Dihexas trajectoryfrom claims of being seven orders of magnitude more potent than BDNF in rodents to a failed Phase 2/3 trial and retracted foundational researchexemplifies this valley of death. This pattern demands particular caution when extrapolating from compelling animal data to expectations for human cognitive benefit

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Erythrocytes as a preferential target of oxidative stress in blood

This protective mechanism occurs via the regulation of the P53/SLC7A11 pathway in 661 W cells exposed to hydrogen peroxide-induced oxidative stress (247)

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Furthermore, the GSH-dependent antioxidant enzymes (glutathione peroxidase-1, glutathione reductase, glutathione S-transferase) cooperate and are interconnected reactions that eliminate ROS or controlled the redox state