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The most commonly reported side effects, usually mild, are related to the digestive system and include bloating , abdominal cramps , or general stomach discomfort

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Most presented with hemiparesis, and hospital stays were longer for women than men.5% of acute strokes were thrombolysed.The most common complication was pneumonia 20%

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For patients whose clinical situation requires moderate rather than maximal weight loss, such as those with early-stage metabolic dysfunction where 10-12% weight loss is sufficient to normalize metabolic parameters, orforglipron's efficacy profile may be adequate and its oral convenience advantageous