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Unlike approved medications, these products havent been reviewed for safety, effectiveness, or quality before hitting the market.

Some individuals experience reflux during dose escalation phases, while others notice symptoms level off as their bodies adapt over 4-8 weeks

Bioconjug Chem 1997

High-dose oral formulations, extended indications, and combination therapies are under ongoing investigation and may further broaden clinical utility

However, for a subset of patients, gastrointestinal symptoms can be persistent and may affect treatment adherence